传出细胞增多
平衡
生物
细胞生物学
吞噬作用
细胞凋亡
疾病
免疫学
巨噬细胞
病理
医学
生物化学
体外
作者
Sho Morioka,Christian Maueröder,Kodi S. Ravichandran
出处
期刊:Immunity
[Elsevier]
日期:2019-05-01
卷期号:50 (5): 1149-1162
被引量:222
标识
DOI:10.1016/j.immuni.2019.04.018
摘要
Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by the process of efferocytosis that is anti-inflammatory. However, a number of pathologies have recently been linked to defective clearance of apoptotic cells. Perturbed clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at different stages of efferocytosis, and responses of phagocytes during efferocytosis, all of which can alter the homeostatic tissue environment. This review covers linkages of molecules involved in the different phases of efferocytosis to disease pathologies that can arise due to their loss or altered function.
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