芳香烃受体
肺动脉高压
细胞色素P450
药物代谢
芳香烃受体核转运体
医学
肺
雌激素受体
炎症
药理学
新陈代谢
生物信息学
生物
内科学
内分泌学
生物化学
癌症
乳腺癌
转录因子
基因
作者
Grażyna Kwapiszewska,Anne Katrine Johansen,José Gomez-Arroyo,Norbert F. Voelkel
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2019-07-19
卷期号:125 (3): 356-366
被引量:17
标识
DOI:10.1161/circresaha.119.315054
摘要
Rationale: CYPs (cytochrome p450) are critically involved in the metabolism of xenobiotics and toxins. Given that pulmonary hypertension is strongly associated with environmental exposure, we hypothesize that CYPs play a role in the development and maintenance of pathological vascular remodeling. Objective: We sought to identify key CYPs that could link drug or hormone metabolism to the development of pulmonary hypertension. Methods and Results: We searched in Medline (PubMed) database, as well as http://www.clinicaltrials.gov , for CYPs associated with many key aspects of pulmonary arterial hypertension including, but not limited to, severe pulmonary hypertension, estrogen metabolism, inflammation mechanisms, quasi-malignant cell growth, drug susceptibility, and metabolism of the pulmonary arterial hypertension–specific drugs. Conclusions: We postulate a hypothesis where the AhR (aryl hydrocarbon receptor) mediates aberrant cell growth via expression of different CYPs associated with estrogen metabolism and inflammation.
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