A novel symmetrical cyclooctenone from Radix Glycyrrhizae

A novel symmetrical structure, Gancao cyclooctenone A (1), was isolated from Radix Glycyrrhizae. The structure of the compound was established on the basis of the spectroscopic data including 1D and 2D NMR spectroscopy and mass spectrometry. Cytotoxic activities of compound 1 on A549 and Hela cell lines were evaluated and the IC50 values were determined to be 63.21 and 45.82 μΜ, respectively.