Proteomics analysis of E-cadherin knockdown epithelial breast cancer cells

E-cadherin is the core protein of the epithelial adherens junction. Through its cytoplasmic domain, E-cadherin interacts with additional proteins among which catenins that bridge it to the actin cytoskeletal. Loss of E-cadherin expression is considered a crucial step in the epithelial–mesenchymal transition process (EMT) and it is implicated with the capacity of cancer cells to invade and metastasize.