Observation of effect on Entecavir in the treatment of hepatitis B cirrhosis

Objective To observe clinical effect of hepatitis B cirrhosis treated with Entecavir.Methods 88 patients with hepatitis B cirrhosis were divided into treatment group(44 patients) and control group(44 patients) randomly.The control group received conventional liver-protecting and symptomatic treatment only,while the treatment group received additional Entecavir(0.5 mg/d,one year course).The liver function,Child-Pugh grade,HBV DNA and liver fibrosis markers(HA,LN,PⅢP and Ⅳ-C) of two groups were observed.Results The total effective rate of treatment group(95.5%) was higher than control group(63.6%)(P 0.01).After treatment,the liver fibrosis markers(HA,LN,PⅢP and Ⅳ-C),liver function and Child-Pugh grade in both groups were significantly improved(P 0.05).There were significant differences of liver fibrosis markers(HA,LN,PⅢP and Ⅳ-C),liver function,Child-Pugh grade and HBV DNA between treatment group and control group after treatment(P 0.05).Conclusion Entecavir has significant clinical effect,low adverse reaction and good tolerance in treating patients with hepatitis B cirrhosis.