Agricultural non-point source pollution is one of the major reasons,which causes watershed pollution in China.However,mathematic model is an important tool in the research of watershed pollution,water quality analysis and forecast.After synthetically analyzing the advantages and disadvantages of non-point source pollution at present,the more advanced and perfect distributed hydrological model—SWAT model was selected,using GIS and RS technology,the study on agricultural non-point source pollution simulation in Erhai Lake Watershed was carried out,and non-point source pollution condition was understood to provide a reasonable reference and basis for the comprehensive management and plan of Erhai Lake Watershed.