对映体药物
化学
胺化
还原胺化
对映体过量
生物催化
辅因子
组合化学
级联反应
醇脱氢酶
胺气处理
级联
氧化还原
对映体
对映选择合成
酒
有机化学
立体化学
酶
催化作用
反应机理
色谱法
作者
Feifei Chen,Youyan Liu,Gao‐Wei Zheng,Jian‐He Xu
出处
期刊:Chemcatchem
[Wiley]
日期:2015-10-22
卷期号:7 (23): 3838-3841
被引量:101
标识
DOI:10.1002/cctc.201500785
摘要
Abstract Multienzyme cascade approaches for the synthesis of optically pure molecules from simple achiral compounds are desired. Herein, a cofactor self‐sufficient cascade protocol for the asymmetric amination of racemic secondary alcohols to the corresponding chiral amines was successfully constructed by employing an alcohol dehydrogenase and a newly developed amine dehydrogenase. The compatibility and the identical cofactor dependence of the two enzymes led to an ingenious in situ cofactor recycling system in the one‐pot synthesis. The artificial redox‐neutral cascade process allowed the transformation of racemic secondary alcohols into enantiopure amines with considerable conversions (up to 94 %) and >99 % enantiomeric excess at the expense of only ammonia; this method thus represents a concise and efficient route for the asymmetric synthesis of chiral amines.
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