黑腹果蝇
多巴胺
生物
多巴胺能
神经科学
果蝇属(亚属)
光遗传学
昼夜节律
细胞生物学
内科学
多巴胺受体
内分泌学
作者
Jia Jia,Lei He,Junfei Yang,Yichun Shuai,Jingjing Yang,Yalan Wu,Xin Liu,Tianli Chen,Guaxiu Wang,Xingyu Wang,Xiaoxu Song,Zhaowen Ding,Yan Zhu,Li Zhang,Peng Chen,Hongtao Qin
标识
DOI:10.1073/pnas.2023674118
摘要
Chronic stress could induce severe cognitive impairments. Despite extensive investigations in mammalian models, the underlying mechanisms remain obscure. Here, we show that chronic stress could induce dramatic learning and memory deficits in Drosophila melanogaster The chronic stress-induced learning deficit (CSLD) is long lasting and associated with other depression-like behaviors. We demonstrated that excessive dopaminergic activity provokes susceptibility to CSLD. Remarkably, a pair of PPL1-γ1pedc dopaminergic neurons that project to the mushroom body (MB) γ1pedc compartment play a key role in regulating susceptibility to CSLD so that stress-induced PPL1-γ1pedc hyperactivity facilitates the development of CSLD. Consistently, the mushroom body output neurons (MBON) of the γ1pedc compartment, MBON-γ1pedc>α/β neurons, are important for modulating susceptibility to CSLD. Imaging studies showed that dopaminergic activity is necessary to provoke the development of chronic stress-induced maladaptations in the MB network. Together, our data support that PPL1-γ1pedc mediates chronic stress signals to drive allostatic maladaptations in the MB network that lead to CSLD.
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