Total Synthesis of Mycocyclosin and the Herqulines

Abstract Since the first reports of their isolation, mycocyclosin and the herquline family of natural products have attracted interest from the synthetic community for their uniquely strained macrocyclic architectures. This review describes the attempted and successful total syntheses of these natural products and provides a summary of the strategies developed in the years since their isolation. 1 Introduction 2 Biosynthesis 3 Early Studies 4 Total Synthesis of Mycocyclosin 5 Overview 6 Wood’s Total Syntheses of Herqulines B and C 7 Baran’s Total Syntheses of Herqulines B and C 8 Schindler’s Total Syntheses of Herqulines B and C 9 Conclusions