骨关节炎
医学
软骨
血管生成
软骨下骨
骨髓
病理
关节软骨
解剖
内科学
替代医学
作者
Hu Yan,Xiao Chen,Wang Sicheng,Yingying Jing,Jiacan Su
出处
期刊:Bone research
[Springer Nature]
日期:2021-03-17
卷期号:9 (1)
被引量:187
标识
DOI:10.1038/s41413-021-00147-z
摘要
Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden. The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends. Basic and clinical research on osteoarthritis has been carried out for decades, but many questions remain unanswered. The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear. Accumulating evidence shows that subchondral bone lesions, including bone marrow edema and angiogenesis, develop earlier than cartilage degeneration. Clinical interventions targeting subchondral bone have shown therapeutic potential, while others targeting cartilage have yielded disappointing results. Abnormal subchondral bone remodeling, angiogenesis and sensory nerve innervation contribute directly or indirectly to cartilage destruction and pain. This review is about bone-cartilage crosstalk, the subchondral microenvironment and the critical role of both in osteoarthritis progression. It also provides an update on the pathogenesis of and interventions for osteoarthritis and future research targeting subchondral bone.
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