CD40
发病机制
受体
自身免疫性脑炎
抗体
免疫学
医学
内科学
内分泌学
生物
自身抗体
生物化学
体外
细胞毒性T细胞
作者
Xiaoyu Ma,Chen Chen,Ling Fang,Xiaonan Zhong,Yanyu Chang,Rui Li,Yuge Wang,Xueqiang Hu,Wei Qiu,Yuelong Shu
标识
DOI:10.1016/j.jneuroim.2021.577762
摘要
Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.
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