Curative Effectiveness of Nimodipine Given by 2 Different Routes in the Treatment of Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

OBJECTIVE:To probe into the curative effectiveness of nimodipin given by 2 different routes in the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage(SAH). METHODS:68 patients with primary aneurysmal subarachnoid hemorrhage were randomized into nimodipine with intravenous administration group and nimodipine with oral administration group. Transcranial Doppler(TCD)was used to detect blood flow velocity(BFV),incidence of cerebra1 vasospasm,rebleeding and the mortality rates in 2 groups. Curative effectiveness of nimodipine given by 2 different routes was evaluated. RESULTS:BFV was significantly improved after 21 days of treatment. Significant difference was noted before and after treatment(P0.05). Neurologic impairment score after 21 days of treatment was significantly different from before treatment(P0.05). The improvement of neurologic function in nimodipine with oral administration group was superior to in nimodipine with intravenous administration while there was no significant difference in 2 groups(P0.05). Rates of cerebra1 vasospasm and rebleeding and the mortality of 2 groups were significantly decreased with mild side effect. No significant difference was noted between 2 groups(P0.05). CONCLUSION:Nimodipine has a certain clinical effect on aneurysmal subarachnoid hemorrhage. There was no statistical significance between 2 different routes.