Comparison of Enrichment Effect of Iridoid Glycosides from Cornus officinalis by Different Macroporous Resins

Objective: To investigate separation effect of iridoid glycosides from Cornus officinalis by different types of macroporous resin.Method: The content of loganin and morroniside from C.officinalis was determined by HPLC,effectiveness of different macroporous adsorption resin on separating iridoid glycosides from C.officinalis was investigated.Result: HPD-400 type of macroporous resin had the best separation effect.Regression equation of loganin and morroniside were Y = 17.245X + 13.362(r = 0.999 9),Y = 15.468X 41.275(r = 1.000 0);The linear range of them were 21.75-435,35.8-716 μg;Recoveries were 98.27%,96.29%,respectively.Conclusion: It was feasible that selected the content of loganin and morroniside as index to screen macroporous resin for enrichment iridoid glycosides from C.officinalis,this study could provide experimental basis for the follow-up study of separation of effective parts from C.officinalis.