Effect of Ethyl Acetate Fractions in Magnolia officinalis and Ginger Magnolia officinalis on Gastrointestinal Motility Function in Mice

Objective: To compare the effect of ethyl acetate fractions in Magnolia officinalis and ginger M. officinalis on gastrointestinal motility function. Method: SPF Kunming mice were randomly divided into high,medium and low dose group,positive and negative control group. The dosage for mice was 1,2 and 3 times the highest M. officinalis for adult. After 3 days of administration,the effect of gastrointestinal motility function was evaluated by the intestinal propulsion rate,ulceration caused by hydrochloric acid and contents of the gastrin.Result: There was significant difference between test groups and negative contrast groups in the intestinal propulsion rate( P 0. 05),and no significant difference between test groups and positive contrast groups. There was significant difference between test groups and negative contrast groups on inhibition of gastric ulcer( P 0. 05).There were significant difference between medium dosage of ginger M. officinalis,low dosage of M. officinalis and negative contrast group on contents of the gastrin( P 0. 05). There was no significant difference between medium dosage of ginger M. officinalis and positive contrast groups. Conclusion: The ethyl acetate fractions extracted from M. officinalis and ginger M. officinalis may promote gastrointestinal motility and protect gastric mucosa. The effect of ginger M. officinalis is better than that of M. officinalis.