Botulinum neurotoxin(BoNT) is the most poisonous neurotoxin and can cause flaccid paralysis as a result of inhibition of acetylcholine release at the neuromuscular junction,inducing corresponding clinical symptoms.Alimentary toxicosis is most common.Botulinum neurotoxin threaten human′s healthiness possibly as biological weapon.It is important to diagnose and treat the Botulinum neurotoxin poisoning.The essay summarizes the advance in diagnose and cure toxicosis of Botulinum neurotoxin concisely.