Preparation and Anticancer Effects of Vincristine Carried with Long-circulating Liposomes

Objective: To prepare long-circulating vincristineloaded liposomes and study its acute toxicity and anticancer effects.Methods: The acute toxicity was evaluated with single dose administration and the anticancer effects was evaluated using a subcutaneously transplanted tumor model.Results: The size distribution of the long-circulating liposomess was from 80 to 150 nm.The acute toxicity of doxorubicin was significantly lowered while its anticancer effects were significantly raised in comparisons with free vincristine.Conclusions: Long-circulating liposome is a good drug delivery system for vincristine.