Bacillus thuringiensis and Bacillus sphaericus are currently used to combat the mosquitoes.Bacillus thuringiensis mosquitocidal toxins belong to tow structurally different groups: the Cry family and the Cyt family.Bacillus sphaericus insecticidal activities come from binary toxin.These approaches isolated new strains and toxic protein genes and found the interaction of toxins,hoped to increase the efficacy of biological mosquitoes control.