Isolation of Triterpenoid Glycosides (Saikosaponins) fromBupleurum polyclonumY. LietS. L. Pan and Their Chemical Structures

Sixteen triterpenoid glycosides, named S13 to S25, S37, S38 and S40, were isolated from the root of Bupleurum polyclonum Y. Li et S. L. Pan, and their structures were determined from NMR spectral analyses.Among them, S24, S37 and S38 were found to be new substances, their structures being established as 30-/?-D-glucopyranosyl 30-hydroxysaikosaponin-b2, 2 "-<9-acetylsaikosaponin-b2 and 3/ /-0-acetylsaikosaponin-b2, respectively.Bupleurum plants are well-known traditional Chinese drugs and are often utilized to treat common cold with fever, alternating chill and fever, the feeling of fullness and oppression in the chest, and hypochondria.They have been accepted for medical use in China f or more than two thousand years.Recently, two of the authors have discovered in Yunnan Province, China, two new species in Bupleurum genus, named B. kunmingense Y.