Synthesis of Some Thiazino-pyrazoles as Potential Fungicides

Arylmethylene-2,4-dihydro-2-arylthioanilido-5-methyl-3H-pyrazol-3-ones(2) were prepared by the condensation of 2,4-dihydro-2-arylthioanilido-5-methyl- 3H- pyrazol - 3- ones (1) with aromatic aldehydes in the presence of glacial acetic acid. The synthesized compounds (2) reacted with phenyl thiourea in presence of alcoholic KOH at reflux temperature to give 1- arylthioanilido-3-methyl-4-aryl-6-phenylimino -4,7- dihydro-1, 3- thiazino (5,4-d) pyrazoles (3). The synthesised compounds (3) have been screened for their fungicidal activities against fungi A. fumigatus and C. albicans at different concentrations.