Implications of partial plasma coagulation factor activity in acute coronary syndrome

Objective To investigate the activity of partial plasma coagulation factor activity and its clinical significance in occurrence of acute coronary syndrome(ACS).Methods The activities of co- agulation factors(FV:C,FⅦ:C,FⅧ:C,FⅩ:C and FⅪ:C) were measured in 100 patients with acute myocardial infarction(AMI group) and 69 patients with unstable angina pectoris in acute stage(UAP group),the results were compared with those of 120 cases of stable angina pectoris(SAP group) and 80 healthy controls(healthy control group).The relationship was analyzed between activities of coagu- lation factors and AMI as well as acute stage UAP.Results The patients with acute myocardial infarc- tion and unstable angina pectoris in acute phase had significantly higher plasma FⅤ:C,FⅦ:C,FⅧ: C,FⅩ:C and FⅪ:C compared with those of healthy and SAP subjects(P0.05);there were no sig- nificant differences of the above activities between SAP group and healthy control group(P0.05). Conclusion Significantly higher activation of FⅤ:C,FⅦ:C,FⅧ.-C,FⅩ:C and FⅪ:C and a hyper- coagulabale state exist in acute coronary syndrome(ACS) patients in acute stage.