A new synthetic method and characterization of miriplatin,an antitumor drug

Miriplatin(1),a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma.A new synthetic route was designed and used to prepare the target compound.The key intermediate Pt(C6H14N2)(OH)2(2),synthesized from Pt(C6H14N2)I2 with AgNO3 and Ba(OH)2·8H2O,was subsequently reacted with CH3(CH2)12COOH in n-butanol to give target compound with satisfied yield 68%(based on Pt(C6H14N2)I2).The structure of the target compound was identified by elemental analysis.ESI-MS,FT-IR,1H-NMR and thermal analysis.And the structure was consistent with the target compound.Compared with reported methods,the new starting compound Pt(C6H14N2)I2 replacing the Pt(C6H14N2)Cl2 is convenient for controlling the Ag+,and using n-butanol-H2O as the reaction medium can achieve a desirable reaction rate,however a large amount of CH3(CH2)12COONa in the product was not easy to be removed.In addition,using n-butanol is less harmful than chloroform to human body.