Phthalide metabolites produced by mangrove endophytic fungus Pestalotiopsis sp. SAS4

Abstract Two new phthalide derivatives ( 1 – 2 ) and four known phthalide compounds ( 3 – 6 ) were purified from the culture of a mangrove endophytic fungus Pestalotiopsis sp. SAS4. Their chemical structures were established by analyses of 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR‐MS) spectroscopic data. All of these compounds were evaluated in vitro for antibacterial, cytotoxicity, and resistance to hypoxic–ischemic injury activities.