骨不连
医学
非工会
重症监护医学
骨科手术
人口
欧洲联盟
反动的
骨愈合
物理疗法
外科
业务
法学
经济政策
环境卫生
政治
政治学
作者
Joseph R. Chitwood,Nabarun Chakraborty,Rasha Hammamieh,Sharon M. Moe,Neal X. Chen,Melissa A. Kacena,Roman M Natoli
出处
期刊:Biomarkers
[Informa]
日期:2021-10-03
卷期号:26 (8): 703-717
被引量:5
标识
DOI:10.1080/1354750x.2021.1985171
摘要
Fracture non-union is a significant orthopaedic problem affecting a substantial number of patients yearly. Treatment of nonunions is devastating to patients and costly to the healthcare system. Unfortunately, the diagnosis of non-union is typically made in a reactionary fashion by an orthopaedic surgeon based on clinical assessment and radiographic features several months into treatment. For this reason, investigators have been trying to develop prediction algorithms; however, these have relied on population-based approaches and lack the predictive capability necessary to make individual treatment decisions. There is also a growing body of literature focussed on identifying blood biomarkers that are associated with non-union. This review describes the research that has been done in this area. Further studies of patient-centered, precision medicine approaches will likely improve fracture non-union diagnostic/prognostic capabilities.
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