褐藻糖胶
肾脏疾病
医学
糖尿病肾病
肾
MAPK/ERK通路
纤维化
炎症
肾病
生物信息学
药理学
生物
内科学
信号转导
内分泌学
糖尿病
多糖
生物化学
作者
Md. Sarwar Zahan,Adeba Hasan,Md. Hasanur Rahman,Kamrun Nahar Meem,Akhi Moni,Md. Abdul Hannan,Jamal Uddin
标识
DOI:10.1016/j.ijbiomac.2022.04.192
摘要
Chronic kidney disease (CKD) is a major public health concern that costs millions of lives worldwide. Natural products are consistently being explored for the development of novel therapeutics in the management of CKD. Fucoidan is a sulfated polysaccharide predominantly extracted from brown seaweed, which has multiple pharmacological benefits against various kidney problems, including chronic renal failure and diabetic nephropathy. This review aimed at exploring literature to update the renoprotective effects of fucoidan, to get an understanding of pharmacological mechanisms, and to highlight the recent progress of fucoidan-based therapeutic development. Evidence shows that fucoidan is effective against inflammation, oxidative stress, and fibrosis in kidney. Fucoidan targets multiple signaling systems, including Nrf2/HO-1, NF-κB, ERK and p38 MAPK, TGF-β1, SIRT1, and GLP-1R signaling that are known to be associated with CKD pathobiology. Despite these pharmacological prospects, the application of fucoidan is limited by its larger molecular size. Notably, low molecular weight fucoidan has shown therapeutic promise in some recent studies. However, future research is warranted to translate the outcome of preclinical studies into clinical use in kidney patients.
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