代谢物
天然产物
化学
次生代谢物
立体化学
传统医学
生物化学
医学
基因
作者
Sing Yee Yeung,Matthew Piggott
出处
期刊:Fitoterapia
[Elsevier]
日期:2017-11-01
卷期号:123: 9-12
被引量:1
标识
DOI:10.1016/j.fitote.2017.08.019
摘要
Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.
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