肿胀 的
自愈水凝胶
热重分析
葡甘露聚糖
化学
药物输送
控制释放
核化学
生物材料
化学工程
高分子化学
材料科学
有机化学
纳米技术
复合材料
生物化学
工程类
作者
Chongyang Zhu,Xiaojun Zhang,Jing Gan,Geng Dong,Xiaojia Bian,Yongqiang Cheng,Ning Tang
标识
DOI:10.1016/j.ijbiomac.2023.123392
摘要
The pH-sensitive hydrogel consisting of carboxymethylated konjac glucomannan (CMKGM) and sodium trimetaphosphate (STMP) was prepared for a potential intestinal targeted delivery system. Both the CMKGM and the CMKGM hydrogel were characterized by FT-IR spectra, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The Congo red and atomic force microscope (AFM) results showed a coil-to-helix transition of CMKGM in alkaline conditions with the degree of substitution (DS) increased from 0.20 to 0.49. Rheological measurements indicated that the DS and the STMP content collectively influence the mechanical stiffness and swelling properties of the obtained hydrogels. In addition, the swelling behavior of the hydrogels revealed that they were sensitive to pH value changes and were following a Korsmeyer-Peppas gastrointestinal release behavior, indicating that the release was controlled by non-Fickian diffusion. Furthermore, all the results suggested that the prepared pH-sensitive hydrogel may serve as a potential biomaterial for the intestine-targeted delivery system.
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