姜黄素
透明质酸
伤口愈合
成纤维细胞
细胞外基质
体内
再生(生物学)
化学
生物医学工程
药理学
医学
外科
体外
生物化学
生物技术
解剖
细胞生物学
生物
作者
Xiaoxia Wang,Guojuan Fan,Qingyan Guan,Liping Zhao,Fengshuo Sun,Huijie Yang,Jiaxuan Zhao,Jingqi Zhang,Hua Wang,Weifen Zhang,Jinlong Ma
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-11-02
卷期号:5 (11): 16094-16107
被引量:9
标识
DOI:10.1021/acsanm.2c02706
摘要
Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence, the need for medication is not constant throughout the stage of burn recovery. In this study, we construct a nano self-adaption release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8 (ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound for the treatment of burns. The release of Cur within 48 h in the media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%, which could realize antibacterial functions in the inflammation stage, wound healing in the tissue proliferation/formation stage, and prevention of excessive fibroblast development and aberrant extracellular matrix deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system with antibacterial wound-healing properties and prevents scarring functional based on the ZIF8-HA nano-vehicle, which opens a new way for the clinical application of curcumin for burn healing.
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