The Toulouse algorithm: vulvar cancer location-based reconstruction

Vulvar cancer is a rare malignancy, accounting for approximately 5% of all gynecological cancers, but its incidence has increased. The gold standard treatment is complete surgical resection with safety margins, which may vary according to histological subtype. This surgery often results in large defects, which may be challenging to repair international guidelines recommend that reconstructive procedures after vulvar cancer surgery should always be considered in cases where it will guarantee better functional and/or cosmetic results or when wound closure will be challenging. With the advancements of reconstructive procedures in oncologic surgery, perforator flaps represent the best option to reduce donor-site complications, and have all the advantages for vulvar reconstruction, by less demolitive procedures to maintain the patient's self-image and sexual function without impacting the oncological outcome. Various algorithms have been proposed in the literature for flap selection in vulvo-perineal reconstructive surgery (Gentileschi S, Servillo M, Garganese G, et al. Surgical therapy of vulvar cancer: how to choose the correct reconstruction? J Gynecol Oncol. 2016;27(6):e60. doi:10.3802/jgo.2016.27.e60; Negosanti L, Sgarzani R, Fabbri E, et al. Vulvar reconstruction by perforator flaps: algorithm for flap choice based on the topography of the defect. Int J Gynecol Cancer. 2015;25(7):1322-1327. doi:10.1097/IGC.0000000000000481; Salgarello M, Farallo E, Barone-Adesi L, et al. Flap algorithm in vulvar reconstruction after radical, extensive vulvectomy. Ann Plast Surg. 2005;54(2):184-190. doi:10.1097/01.sap.0000141381.77762.07; Höckel M, Dornhöfer N. Vulvovaginal reconstruction for neoplastic disease. Lancet Oncol. 2008;9(6):559-568. doi:10.1016/S1470-2045(0870147-5)). However, these often lack practicality as they are based on the size of the defect, listing all possible flaps that can be adopted without considering that some flaps should clearly be preferred because of their better aesthetic result. Moreover, most of these algorithms still recommend musculocutaneous flaps which are associated with greater donor-site morbidity, and which should therefore be considered only in selected cases when other flaps are not feasible. We present a simple and effective algorithm for flap selection in the field of vulvo-vaginal-perineal reconstruction for vulvar carcinomas, developed from our experience as a tertiary referral cancer center. This algorithm is based on the anatomical involvement of the vulvo-perineal region to provide more accurate anatomical restoration. It is versatile enough to be used in most cases of vulvo-vagino-perineal reconstructive surgery, leading to an improvement in the restoration of anatomy and function. Moreover, perforator flaps are proposed as the first option with different possibilities based on the location and the size of the defect.