二氟卡宾
三苯基膦
叶立德
亲核细胞
化学
磷
有机化学
催化作用
作者
A. V. Trifonov,Alexander D. Dilman
标识
DOI:10.1002/chem.202303144
摘要
A metal-free one-pot process for the gem-difluoroolefination of amides is described. The reaction is based on interaction of generated in situ α-chloroiminium salts with difluorinated phosphorus ylide formed from difluorocarbene and triphenylphosphine. The olefination involves nucleophile-assisted dephosphorylation and proceeds within one hour at low temperature. The gem-difluoroenamines were used in further transformations leading to a variety of fluoroalkylated amines.
科研通智能强力驱动
Strongly Powered by AbleSci AI