内质网
平衡
生物
细胞生物学
钙信号传导
细胞器
钙代谢
钙
癌细胞
细胞信号
癌症
细胞内
信号转导
内科学
医学
遗传学
作者
S. Zheng,Xingwen Wang,Zhao Dong,Hao Líu,Ying Hu
标识
DOI:10.1016/j.tcb.2022.07.004
摘要
Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule controlling a wide variety of cellular processes, such as proliferation, cell death, migration, and immune response, all fundamental processes essential for the establishment of cancer. In recent decades, the loss of Ca2+ homeostasis has been considered an important driving force in the initiation and progression of malignant diseases. The primary intracellular Ca2+ store, the endoplasmic reticulum (ER), plays an essential role in maintaining Ca2+ homeostasis by coordinating with other organelles and the plasma membrane. Here, we discuss the dysregulation of ER-centered Ca2+ homeostasis in cancer, summarize Ca2+-based anticancer therapeutics, and highlight the significance of furthering our understanding of Ca2+ homeostasis regulation in cancer.
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