海绵
立体化学
化学
发酵
质谱法
抗菌剂
细胞毒性
体外
葡萄糖醛酸
色谱法
生物化学
有机化学
生物
代谢物
植物
作者
Die Zhang,Jing Xu,Qi Qin,Faliang An,Shuping Wang,Lei Li,Hou-Wen Lin
标识
DOI:10.1038/s41429-022-00552-4
摘要
A new member of β-carboline alkaloids, Marinacarboline glucuronide (1), along with nine known compounds (2-10), were isolated from static liquid fermentation extracts of Actinoalloteichus cyanogriseus LHW52806 isolated from the marine sponge Phakellia fusca. Their structures were elucidated by NMR, mass spectrometry and single-crystal X-ray diffraction. All compounds exhibited neither antimicrobial activity nor cytotoxicity. Compounds 1, 8 and 10 showed anti-inflammatory potential of significant decreasing the expressions of IL- 6 in vitro at 20 µM.
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