乳腺癌
小胶质细胞
癌症
医学
脑转移
转移
坦克结合激酶1
转移性乳腺癌
癌症研究
内科学
信号转导
肿瘤科
乳腺癌转移
作者
Fatima Khan,Edgar Petrosyan,Yang Liu,Atousa Bahrami,Erfan Taefi,Changiz Geula,Maciej S. Lesniak,Peiwen Chen
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-09-18
卷期号:86 (1): 12-21
标识
DOI:10.1158/0008-5472.can-25-1791
摘要
Enrichment and activation of TBK1 in tumor-associated microglia upregulates GM-CSF to promote metastatic properties of breast cancer cells, highlighting TBK1 inhibition as a potential therapeutic opportunity for treating breast cancer brain metastasis.
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