孟德尔随机化
增生
多效性
医学
前列腺
内科学
遗传变异
内分泌学
生物信息学
生理学
生物
遗传学
基因
基因型
癌症
表型
作者
Ze-chao Zhang,Shu-Ping Huang,Ze-sen Lin,Yu Chen,Peng Jiang,Yuwei Yang,Cui Shang,Min Zhu,Hongjun Gao
标识
DOI:10.1007/s40520-023-02669-4
摘要
Abstract Background Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH. Methods In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reverse MR analysis, BPH was employed as an exposure to assess its effects on CM. Results The forward MR analysis discerned a linkage between six metabolites and BPH, with careful consideration to excluding heterogeneity and pleiotropy. Subsequently, the reverse MR analysis unveiled that nine metabolic compounds, mainly comprising phospholipids and triglycerides, potentially exhibit elevated levels in BPH patients. Conclusion Bidirectional MR analysis furnishes genetic insight into the interplay between CM and BPH. The prominence of lipids and triglycerides emerges as significant factors intricately linked to BPH risk.
科研通智能强力驱动
Strongly Powered by AbleSci AI