Platinum Nanoparticles Regulated V 2 C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐Infective Therapy

Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V 2 C MXene's laser irradiation to the near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V 2 C, forming artificial nanoplatforms (Pt@V 2 C). Pt@V 2 C exhibits enhanced PCE (59.6%) and a longer irradiation laser (NIR‐II) due to the surface plasmon resonance effect of Pt NPs and V 2 C. Notably, Pt@V 2 C displays dual enzyme‐like activity with chemodynamic therapy (CDT) and NIR‐II enhanced dual enzyme‐like activity. The biocatalytic mechanism of Pt@V 2 C is elucidated using density functional theory. In an in vivo animal model, Pt@V 2 C effectively eliminates methicillin‐resistant Staphylococcus aureus from deep‐seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT/CDT. Transcriptomic analysis reveals that Pt@V 2 C targets inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia‐amplified biocatalysis with Pt NPs and MXene nanocomposites.