化学
糖基
糖基化
催化作用
糖苷
羧酸
组合化学
分子
磷酸
有机化学
双功能
功能群
生物化学
聚合物
作者
Li Zhang,Wei Zeng,Demeng Xie,Jiangtao Li,Xiaofeng Ma
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-02-08
卷期号:26 (7): 1332-1337
标识
DOI:10.1021/acs.orglett.3c04159
摘要
We disclosed a Ni/CPA cocatalyzed protocol to access diverse C-acyl glycosides under mild conditions with broad functional group compatibility through the coupling of readily available glycosyl bromides and carboxylic esters. The potential application of the methodology was demonstrated by the C-acyl glycosylation of bioactive molecules and the transformation of products to a variety of value-added molecules. Mechanistic studies revealed that CPA might serve as a bifunctional H-bond catalyst to activate carboxylic esters and nickel catalyst.
科研通智能强力驱动
Strongly Powered by AbleSci AI