c-MYC can Form Phase Condensates via its DNA Binding Domain

Abstract The c-MYC oncogene is overexpressed in cancers. Phase condensates are membrane-less cellular compartments in cells. Using the optoDroplet system, which leverages optogenetics for condensate dynamics studies, here we showed c-MYC has the capability to form phase condensates. Moreover, the 3’ terminus of c-MYC, which contains a DNA binding domain but no intrinsic disordered regions, is sufficient to form phase condensates. Our research contributes to a better understanding of c-MYC biology.