免疫系统
生物
肿瘤坏死因子α
多糖
微生物学
白细胞介素
细胞因子
免疫学
生物化学
作者
Yongshuai Jing,Yameng Zhang,Meng Yan,Ruijuan Zhang,Beibei Hu,Shiguo Sun,Danshen Zhang,Yuguang Zheng,Liqing Wu
出处
期刊:Food Chemistry
[Elsevier]
日期:2023-07-01
卷期号:413: 135658-135658
被引量:6
标识
DOI:10.1016/j.foodchem.2023.135658
摘要
Crataegus pinnatifida is a common food in China, Europe and North America. In order to confirm polysaccharide was the material basis for C. pinnatifida to exert immune regulation. A polysaccharide (CPP) with a molecular weight of 13.58 kDa was isolated from C. pinnatifida. The structure of CPP was determined to be a backbone composed of → 3,5)-α-l-Araf-(1→, with two branches consisting of → 4)-α-d-Galp-(1 → and → 5)-α-l-Araf-(1→, with α-l-Araf and α-d-Manp as the terminal unit. CPP (10 ∼ 500 μg/mL) could promote the secretion of nitric oxide, interleukin-2, interleukin-6 and tumor necrosis factor-α in vitro. CPP could significantly restore the body weight of immunosuppressive mice and improve the immune organ index and interleukin-2, interleukin-6, and tumor necrosis factor-α secretion. In addition, CPP increased the abundance of Bacteroidetes and Verrucomicrobia and decreased the abundance of Proteobacteria at the phylum level. So CPP can regulate the gut microbiota and play an important role in immune regulation.
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