LPA 5 -Dependent signaling regulates regeneration of the intestinal epithelium following irradiation

We used mice lacking expression of the lysophosphatidic acid receptor 5 (LPA 5 ) in intestinal epithelial cells and intestinal organoids to show that the LPA 5 receptor protects intestinal stem cells and progenitors from radiation-induced injury. We show that LPA 5 induces YAP signaling and regulates Paneth cells.