The cerebellum tells the amygdala, “Nothing diminishes anxiety faster than action”

In this issue of Neuron, Zhang et al. question the neural substrates of exercise-based alleviation of anxiety in rodents. In brief, they propose a model where physical activity provides an anxiolytic effect by recruiting specific cerebello-limbic circuits. In this issue of Neuron, Zhang et al. question the neural substrates of exercise-based alleviation of anxiety in rodents. In brief, they propose a model where physical activity provides an anxiolytic effect by recruiting specific cerebello-limbic circuits. A role for the cerebellum in motor-triggered alleviation of anxietyZhang et al.NeuronJanuary 31, 2024In BriefThe brain mechanisms by which exercise improves mood remain unclear. Zhang et al. dissect a hypothalamo-cerebello-amygdalar circuit bridging the subcortical motor and limbic systems, through which motor activity quickly regulates anxiety at two levels of intensity, and shed light on developing challenging exercise strategies and cerebellar-targeted interventions for anxiety. Full-Text PDF Open Access