结缔组织增生
纤维腺瘤
前胶原肽酶
恶性肿瘤
病理
纤维囊性疾病
信使核糖核酸
纤维囊性乳腺病
生物
医学
乳腺癌
内科学
基质
癌症
免疫组织化学
基因
遗传学
作者
Susan B. Deak,Maria R. Glaug,Richard A. Pierce,Edita Bancila,Peter S. Amenta,James W. Mackenzie,Ralph S. Greco,Charles D. Boyd
出处
期刊:Matrix
[Elsevier]
日期:1991-08-01
卷期号:11 (4): 252-258
被引量:13
标识
DOI:10.1016/s0934-8832(11)80232-5
摘要
Desmoplasia, the formation of excessive connective tissue surrounding some neoplasms, is a well documented, but incompletely understood phenomenon. To characterize the fibrotic response in benign breast conditions and malignancy, we examined the steady state levels of mRNA coding for types I and III procollagen in mild fibrocystic changes, in fibroadenoma, and in infiltrating ductal carcinoma. The results indicate that in mild fibrocystic change there is a relative increase in type III procollagen mRNA. In contrast, fibroadenoma and carcinoma are characterized by increased levels of type I procollagen mRNA.
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