再生(生物学)
杯状细胞
情感(语言学)
结膜
分泌物
疾病
细胞生物学
生物
免疫学
医学
神经科学
心理学
病理
内科学
上皮
沟通
作者
Shivalingappa K. Swamynathan,Alan Wells
出处
期刊:Ocular Surface
[Elsevier]
日期:2020-01-01
卷期号:18 (1): 19-26
被引量:41
标识
DOI:10.1016/j.jtos.2019.11.005
摘要
Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble mucins to the tear film that bathes the ocular surface. CGC numbers and functions are affected in various ocular surface diseases including dry eye disease with diverse etiologies. In this review we will (i) summarize the important functions of CGCs in ocular surface health, (ii) describe the ocular surface diseases that affect CGC numbers and function, (iii) provide an update on recent research outcomes that elucidate CGC differentiation, gene expression and functions, and (iv) present evidence in support of the prediction that restoring CGC numbers and/or functions is a viable strategy for alleviating ocular surface disorders that impact the CGCs.
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