肿瘤缺氧
肿瘤微环境
光热治疗
放射治疗
催化作用
癌症研究
化学
纳米颗粒
材料科学
生物物理学
纳米技术
肿瘤细胞
生物化学
医学
生物
内科学
作者
Wenhui Fu,Xiao Zhang,Linqiang Mei,Ruyi Zhou,Wenyan Yin,Qiang Wang,Zhanjun Gu,Yuliang Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-07-13
卷期号:14 (8): 10001-10017
被引量:94
标识
DOI:10.1021/acsnano.0c03094
摘要
Development of an efficient nanoradiosensitization system that enhances the radiation doses in cancer cells to sensitize radiotherapy (RT) while sparing normal tissues is highly desirable. Here, we construct a tumor microenvironment (TME)-responsive disassembled small-on-large molybdenum disulfide/hafnium dioxide (MoS2/HfO2) dextran (M/H-D) nanoradiosensitizer. The M/H-D can degrade and release the HfO2 nanoparticles (NPs) in TME to enhance tumor penetration of the HfO2 NPs upon near-infrared (NIR) exposure, which can solve the bottleneck of insufficient internalization of the HfO2 NPs. Simultaneously, the NIR photothermal therapy increased peroxidase-like catalytic efficiency of the M/H-D nanoradiosensitizer in TME, which selectively catalyzed intratumorally overexpressed H2O2 into highly oxidized hydroxyl radicals (·OH). The heat induced by PTT also relieved the intratumoral hypoxia to sensitize RT. Consequently, this TME-responsive precise nanoradiosensitization achieved improved irradiation effectiveness, potent oxygenation in tumor, and efficient suppression to tumor, which can be real-time monitored by computed tomography and photoacoustic imaging.
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