医学
指南
放射治疗
胰腺癌
放化疗
放射治疗计划
医学物理学
疾病
放射科
癌症
内科学
病理
作者
Thomas Brunner,Karin Haustermans,F. Huguet,Alessio Giuseppe Morganti,Somnath Mukherjee,Claus Belka,Robert Krempien,Maria A. Hawkins,Vincenzo Valentini,Falk Roeder
标识
DOI:10.1016/j.radonc.2020.07.052
摘要
Abstract
Despite of the predominant role of chemotherapy and surgery in pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) still has a place in multimodal management of this disease where local tumour sequelae are fatal in about 40% of the patients. RT (chemoradiotherapy and stereotactic body radiotherapy) is used and investigated in the non-metastatic setting as part of definitive treatment strategies, in (neo)adjuvant settings and for locally recurrent disease. The ACROP committee was delegated by ESTRO to recommend target volume delineation for these clinical situations. The guidelines of this document are a result of a structured evaluation of the best available evidence by a panel of international experts in the field. Guidance for treatment planning including diagnostic imaging is provided. Recommendations are given for GTV delineation. The role and the definition of CTV volumes are critically discussed. Aspects of motion management and patient positioning are taken into account for PTV definition. Furthermore, aspects of delineation of organs at risk and of dose constraints are described in both, standard and hypofractionated, settings. This guideline has the purpose to support standardised and optimised processes of RT treatment planning for both, clinical practice and prospective studies.
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