General analysis of the mode interaction in multimode fiber is presented in this paper. By taking local gain into consideration, the general coupled mode equations in multimode active fiber are deduced in the model and the effect of various factors can be analyzed based on the general coupled mode equations. Analytical expression of the beam quality factor is deduced for the optical field emerging from the multimode active fiber. The evolution of the mode power and M2 factor along the fiber are analyzed by numerical evaluations.