生物
遗传学
微卫星
等位基因
SNP公司
基因座(遗传学)
单核苷酸多态性
遗传标记
计算生物学
进化生物学
基因型
基因
作者
Alain Vignal,Denis Milan,Magali SanCristobal,Andre A. Eggen
标识
DOI:10.1186/1297-9686-34-3-275
摘要
During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.
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