瞬时受体电位通道
樟脑
激活剂(遗传学)
感觉系统
受体
热感受器
化学
细胞生物学
生物
神经科学
生物化学
有机化学
作者
Aziz Moqrich,Sun Wook Hwang,Taryn J. Earley,Matt Petrus,Amber N. Murray,Kathryn S. R. Spencer,Mary Andahazy,Gina M. Story,Ardem Patapoutian
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-03-04
卷期号:307 (5714): 1468-1472
被引量:684
标识
DOI:10.1126/science.1108609
摘要
Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These “thermoTRPs” are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (>33°C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.
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