RNA剪接
选择性拼接
小基因
计算生物学
基因
拼接因子
外显子剪接增强剂
医学
生物
遗传学
生物信息学
信使核糖核酸
核糖核酸
作者
María J. Pajares,Teresa Ezponda,Raúl Catena,Alfonso Calvo,Rubén Pı́o,Luis M. Montuenga
标识
DOI:10.1016/s1470-2045(07)70104-3
摘要
Alternative pre-mRNA splicing is a key molecular event that allows for protein diversity. Through this process, a single gene increases its coding capacity by expressing several related proteins with diverse and even antagonistic functions. Aberrant splicing has been found to be associated with various diseases, including cancer. Mutations in splicing regulatory elements within the nucleotide sequence and alterations in the cellular-splicing-regulatory machinery both result in changes in the splicing pattern of many cancer-related genes. The analysis of cancer-specific alternative splicing and its molecular consequences is promising. In this review we summarise the current knowledge on the mechanisms governing abnormal alternative splicing in cancer and the biological consequences associated with the alteration of splicing in some relevant cancer-related genes. The use of alternative splicing as a potential source for new diagnostic, prognostic, predictive, and therapeutic tools is also discussed.
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