Interrupting glioblastoma malignant circuitry: plasticity traps, synaptic blockade, and myeloid reprogramming

The resilience of GBM arises from the interplay of epigenetic plasticity, neural circuit co-option, and myeloid-skewed immunosuppression. A coordinated strategy, kinome-guided targeting plus circuit disruption and myeloid reprogramming, offers a credible path to contain adaptation and improve outcomes.