Palladium‐Catalyzed [3 + 2] Annulation of Spirovinylcyclopropyl Oxindoles: A Ring‐Opening/Annulation Cascade to 1,3‐Dispirocyclopentane Skeletons

A palladium‐catalyzed cascade reaction has been developed for the construction of dispiro cyclopentane‐1,2’‐indanedione‐3,3’’‐indoline frameworks. This strategy resorts to the unique reactivity of stable spirovinylcyclopropyl oxindoles and 2‐arylidene‐1,3‐indanediones, enabling a ring‐opening followed by a [3 + 2] annulation in a single operation. The protocol is distinguished by its mild conditions, high efficiency, as well as broad substrate generality, providing a versatile access to these valuable molecular architectures.