This study explored the biopsychosocial and mental health symptoms of frontline healthcare social workers from working during the COVID-19 pandemic. The two-phase concurrent mixed method study of 35 frontline healthcare social workers occurred between October 2021 and July 2022. The 35 social workers who participated in this two-phase study reported feelings of uncertainty of their biological, psychological, and social safety while working during the COVID-19 pandemic. This uncertainty negatively affected their mental health and contributed to an increase in symptoms of depression and anxiety.